Publications

(Since 1990)

Luebben, W.R., Sharma, N., Nyborg, J.K. Nucleosome eviction and activated transcription require p300 acetylation of histone H3 lysine 14. Proc. Natl. Acad. Sci. USA 107, 19254-19259 (2010). PDF

Szerlong, H.J., Prenni, J.E., Nyborg, J.K., and Hansen, J.C. Activator-dependent p300 Acetylation of Chromatin in Vitro: enhancement of transcription by disruption of repressive nucleosome-nucleosome interactions. J. Biol. Chem., 42, 31954-31964 (2010). PDF

Kim, Y.-M., Geiger, T.R., Egan, D.I., Sharma, N., Nyborg, J.K. The HTLV-1 tax protein cooperates with phosphorylated CREB, TORC2 and p300 to activate CRE-dependent cyclin D1 transcription. Oncogene, 29, 2142-2152 (2010). PDF

Nyborg, J.K., Egan, D., Sharma, N. The HTLV-1 Tax protein: revealing mechanisms of transcriptional activation through histone acetylation and nucleosome disassembly. Biochim. Biophys. Acta. 1799, 266-274 (2010). PDF

Sharma, N. and Nyborg, J.K. The Coactivators CBP/p300 and the Histone Chaperone NAP-1 Promote Transcription-Independent Nucleosome Eviction at the HTLV-1 Promoter. Proc. Natl. Acad. Sci. USA 105, 7959-7963 (2008). PDF

Geiger, T.R., Sharma, N., Kim, Y.-M., and Nyborg, J.K. The HTLV-1 Tax Protein Confers CBP/p300 Recruitment and Transcriptional Activation Properties to Phosphorylated CREB. Mol. Cell. Biol. 28, 1383-1392 (2008). PDF

Kim, Y.-M., Sharma, N. and Nyborg, J.K. Tax and the Proto-Oncogene Bcl-3 Form a Complex that Represses HTLV-I Transcription via Displacement of p300. J Virol. 82, 11939-11947 (2008). PDF

Xie, Z., Geiger, T.R., Johnson, E.N., Nyborg, J.K. and Druey, K.M. RGS13 acts as a nuclear repressor of CREB. Molecular Cell, 31, 660-670 (2008). PDF

Gieger, T.R., Sharma, N., Kim, Y.-M., and Nyborg, J.K. The HTLV-1 Tax Protein Confers CBP/p300 Recruitment and Transcriptional Activation Properties to Phosphorylated CREB. Mol. Cell. Biol. in press (2007). PDF

Ramírez, J.A. and Nyborg, J.K. Molecular Characterization of the HTLV-1 Tax Interaction with the KIX Domain of CBP/p300. J. Mol. Biol. 372, 958-969 (2007). PDF

Lopez, D.I., Mick, J.E., and Nyborg, J.K. Purification of CREB to Apparent Homogeneity: Removal of Truncation Products and Contaminating Nucleic Acid. Protein Expression and Purification 55, 406-418 (2007). PDF

Sharma, N., Lopez, D.I. and Nyborg, J.K. DNA Binding and Phosphorylation Induce Conformational Alterations in the Kinase Inducible Domain of CREB: Implications for the Mechanism of CREB Transcription Function. J. Biol. Chem. 282, 19872-19883 (2007). PDF

Kim, Y.-M., Ramírez, J.A., Mick, J.E., Giebler, H.A., Yan, J.-P. and Nyborg, J.K. Molecular Characterization of the Tax-containing HTLV-1 Enhancer Complex Reveals a Prominent Role for CREB Phosphorylation in Tax Transactivation. J. Biol. Chem. 282, 18750-18757 (2007). PDF

Lemasson, I., Lewis, M., Hivin, P., Cavanagh, M-H., Polakowski, N., Thébault, S., Barbeau, B., Nyborg, J.K. and Mesnard, J.M. HTLV-1 bZIP protein interacts with the cellular transcription factor CREB to inhibit HTLV-1 transcription. J. Virology 81, 1543-1553 (2007). PDF

Konesky, K.L., Nyborg, J.K. and Laybourn, P.J. Tax Abolishes Histone H1 Repression of p300 Acetyltransferase Activity at the HTLV-I Promoter. J. Virology, 80, 10542-10553 (2006). PDF

Lemasson, I., Polakowski, N., Laybourn, P.J. and Nyborg, J.K. Tax-Dependent Displacement of Nucleosomes During transcriptional Activation of Human T-cell Leukemia Virus Type 1. J. Biol. Chem. 281,13075-13082 (2006). PDF

Nyborg, J.K. and Peersen, O.B. That Zincing Feeling: The Effects of EDTA on the Behavior of Zinc-Binding Transcriptional Regulators. Biochem. J. 381, e3-e4 (2004). PDF

Lemasson, I., Polakowski, N.J., Laybourn, P.J., and Nyborg, J.K. Transcription Regulatory Complexes Bind the Human T-cell Leukemia Virus 5’ and 3’ Long Terminal Repeats to Control Gene Expression. Mol. Cell. Biol. 24, 6117-6126 (2004). PDF

Livengood, J.A. and Nyborg, J.K. The High Affinity Sp1 Binding Site in the HTLV-1 Promoter Contributes to Tax-Independent Basal Expression. Nuc. Acids Res. 32, 2829-2837 (2004). PDF

Livengood, J.A., Fechter, E.J., Dervan, P.E., and Nyborg, J.K. Paradoxical Effects of DNA Binding Polyamides on HTLV-I Transcription. Frontiers in Bioscience 9, 3058-3067 (2004). PDF

McBryant, S.J., Park, Y.-J., Abernathy, S.M., Laybourn, P.J., Nyborg, J.K. and Luger, K. Preferential binding of the histone (H3-H4)2 tetramer by NAP1 is mediated by the amino terminal histone tails. J. Biol. Chem. 278, 44574-44583 (2003). PDF

Georges, S.A., Giebler, H.A., Cole, P.A., Luger, K., Laybourn, P.J., and Nyborg, J.K. Tax Recruitment of CBP/p300, via the KIX Domain, Reveals a Potent Requirement for Acetyltransferase Activity that is Chromatin-Dependent and Histone Tail-Independent. Mol. Cell. Biol. 23, 3392-3404 (2003). PDF

Lemasson, I, Polakowski, N.J., Laybourn, P.J. and Nyborg, J.K. Transcription Factor Binding and Histone Modifications on the Integrated Proviral Promoter in HTLV‑I‑Infected T‑Cells. J. Biol. Chem. 177, 49459-49465 (2002). PDF

Livengood, J.A., Scoggin, K.E.S., Van Orden, K., Edayathumangalam, R. McBryant, S.J., Laybourn, P.J. and Nyborg. J.K. p53 Interaction with the SRC-Interacting Domain of CBP/p300 Mediates Coactivator-Dependent Transcriptional Activity. J. Biol. Chem. 277, 9054-9061 (2002). PDF

Georges, S. Kraus, W.L., Luger, K. Nyborg, J.K., and Laybourn, P.J. p300-Mediated HTLV-I Tax Transactivation on Recombinant Chromatin Templates: Histone Tail Deletion Mimics Coacti­vator Function. Mol. Cell. Biol. 22, 127-137 (2002). PDF

Scoggin, K. E. S., Ulloa, A. and Nyborg, J.K. The Oncoprotein Tax Binds the SRC-Interacting Do­main of CBP/p300 to Mediate Transcriptional Activation. Mol. Cell. Biol. 16, 5520-5530 (2001). PDF

Lemasson, I. and Nyborg, J.K. HTLV-I Tax Repression of p73b is Mediated Through Competition for the C/H1 domain of CBP. J. Biol. Chem. 276, 15720-15727 (2001). PDF

Mick, J.E., Colgin, M.A. Brauweiler, A. and Nyborg, J. K. Analysis of CREB mutants in Tax complex formation and transactivation. AIDS Research and Human Retroviruses 16, 1597-1601 (2000). PDF

Van Orden, K. and Nyborg, J.K. Insight into CBP function through the viral oncoprotein Tax. Gene Expression. 9, 29-36 (2000). 

Giebler, H.A., Lemasson, I. and Nyborg, J.K. p53 recruitment of CBP mediated through phosphory­lated CREB: A novel pathway for tumor suppressor regulation. Mol. Cell. Biol. 20, 4849-4858 (2000). PDF

Van Orden, K., Giebler, H.A., Lemasson, I., Gonzales, M. and Nyborg, J.K. Binding of p53 to the KIX domain of CBP: A potential link to HTLV-I associated leukemogenesis. J. Biol. Chem. 274, 26321-26328 (1999). PDF

Lenzmeier, B.A., Baird, E.E., Dervan, P.B. and Nyborg, J.K. The Tax Protein-DNA Interaction is Es­sential for HTLV-I Transactivation in vitro. J. Mol. Biol. 291, 731-744 (1999). PDF

Van Orden, K., Yan, J.-P. Ulloa, A. and Nyborg, J.K. Binding of the Human T-Cell Leukemia Virus Tax Protein to the Coactivator CBP Interferes with CBP-mediated Transcriptional Control. Oncogene. 18, 3766-3772 (1999). PDF

Van Orden, K. and Nyborg, J.K. Binding of HTLV-I Tax to the Coactivator CBP Disrupts the Tran­scription Activity of c-Jun, in Molecular Pathogenesis of HTLV-I: a current perspective. eds. O. John Semmes and Marie-Louise Hammarskjold, ABI Professional Publications, (USA) (1999).

Lenzmeier, B.A. and Nyborg, J.K. Molecular Mechanisms of Viral Transcription and Cellular Deregulation Associated with the HTLV-I Tax Protein. Gene Ther. Mol. Biol. 3, 327-345 (1999).

Colgin, M.A. and Nyborg, J.K. The HTLV-I Oncoprotein Tax Inhibits the Transcriptional Activity of c-Myb through Competition for CBP. J. Virol. 72, 9396-9399 (1998). PDF

Yan, J.-P., Garrus, J.E., Giebler, H.A., Stargell, L.A. and Nyborg, J.K. Molecular Interactions Be­tween the Human T-Cell Leukemia Virus Tax Protein and the Cellular Coactivator CBP. J. Mol. Biol. 281, 395-400 (1998). PDF

Brooks, P.A., Cockerell, G.L. and Nyborg. J.K. Activation of BLV Transcription by NF-kB and Tax. Virology 243, 94-98 (1998). PDF

Lenzmeier, B.A., Giebler, H.A. and Nyborg, J.K. HTLV-I Tax Requires Direct Access to DNA for Recruitment of CBP. Mol. Cell. Biol. 18, 721-731 (1998). PDF

Giebler, H.A., Loring, J., Van Orden, K., Colgin, M., Garrus, J., Escudero, K., Brauwieler, A. and Nyborg, J.K. Anchoring of CBP to the HTLV-I Promoter:  A Molecular mechanism of Tax Transactivation. Mol. Cell. Biol. 17, 5156-5164 (1997). PDF

Lenzmeier, B. and Nyborg, J.K. In vitro Transcription of Human T-cell Leukemia Virus Type I is RNA Polymerase II Dependent. J. Virology 71, 2577-2580 (1997). PDF

Brauweiler, A., Garrus, J.E., Reed, J.C. and Nyborg, J.K. Repression of Bax Gene Expression by the HTLV-I Tax Protein:  Implications for Suppression of Apoptosis in Virally-Infected Cells. Virology 231, 135-140 (1997). PDF

Gottesfeld, J.M., Johnson, D.L. and Nyborg, J.K. Transcriptional Activation of RNA Polymerase III-Dependent Genes by the HTLV-I Tax Protein. Mol. Cell. Biol. 16, 1777-1785 (1996). PDF

Uittenbogaard, M.N., Giebler, H.A., Reisman, D. and Nyborg, J.K. Transcriptional Repression of p53 by the Human T-Cell Leukemia Virus type I Tax Protein. J. Biol. Chem. 270, 28503-28506 (1995). PDF

Brauweiler, A., Garl, P., Franklin, A.A., Giebler, H.A. and Nyborg, J.K. A Molecular Mechanism for HTLV-I Latency and Tax Transactivation. J. Biol. Chem. 270, 12814-12822 (1995). PDF

Baranger, A.M., Palmer, C.R., Hamm, M.K., Giebler, H.A., Brauweiler, A., Nyborg, J.K. and Schepartz, A. Mechanism of DNA Binding Enhancement by the HTLV-I Transactivator Tax. Nature 376, 606-608 (1995). PDF

Brooks, P.A., Nyborg, J.K., Cockerell, G.L. Identification of an NF-kapp B binding site in the bovine leukemia virus promoter. J Virol. 69, 6005-6009 (1995). PDF

Uittenbogaard, M.N., Armstrong, A.P., Chiaramello, A., Nyborg, J.K. Human T-cell leukemia virus type I Tax protein represses gene expression through the basic helix-loop-helix family of transcription factors. J. Biol. Chem. 269, 22466-22469 (1994). PDF

Armstrong, A.P., Franklin, A.A., Uittenbogaard, M.N., Giebler, H.A., Nyborg, J.K. Pleiotropic effect of the human T-cell leukemia virus Tax protein on the DNA binding activity of eukaryotic transcription factors. Proc. Natl. Acad. Sci. USA 90, 7303-7307 (1993). PDF

Franklin, A.A., Kubik, M.F., Uittenbogaard, M.N., Brauweiler, A., Utaisincharoen, P., Matthews, M.A., Dynan, W.S., Hoeffler, J.P., Nyborg, J.K. Transactivation by the human T-cell leukemia virus Tax protein is mediated through enhanced binding of activating transcription factor-2 (ATF-2) ATF-2 response and cAMP element-binding protein (CREB). J. Biol. Chem. 268, 21225-21231 (1993). PDF

The Nyborg Lab at Colorado State University © 2012